For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. These may be symptoms of serious mental problems. This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Apart from the commonly noted IRs and DRs, Sim and colleagues describe a type II IgG-mediated allergic reaction which involved a patient who developed ciprofloxacin-induced thrombocytopenia. Cipro, which is used to treat certain bacterial infections, can cause side effects. Learn about its mild and serious side effects and how to manage them. This topic will review hypersensitivity (allergic) reactions to fluoroquinolones. A general discussion of fluoroquinolones, including adverse effects other than hypersensitivity reactions, is found separately. In cases of true penicillin allergy, the source of the reaction is thought to be due to formation of antibodies against metabolites of the penicillin molecule, specifically the R1 side chains of the beta-lactam ring, and not the penicillin molecule or the presence of the beta-lactam ring. This was a study of patients with a ciprofloxacin, moxifloxacin, or levofloxacin hypersensitivity reaction and a documented electronic medical record administration of a different fluoroquinolone. Get emergency medical help if you have signs of an allergic reaction to ciprofloxacin (hives, difficult breathing, swelling in your face or throat, or chest pain and other signs of a heart attack) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling). Understanding the signs of an allergic reaction to ciprofloxacin is crucial for timely intervention and management. This article explores the symptoms, risk factors, and necessary precautions associated with ciprofloxacin allergies. Patients were divided into 3 cohorts according to their index fluoroquinolone allergy (ciprofloxacin, levofloxacin, or moxifloxacin). Within each cohort the frequency of immediate hypersensitivity reactions to second fluoroquinolone was compared.